Table 2.
Multifocal pattern electroretinogram ring analysis of amplitudes and peak times.
| N1 | P1 | N2 | |||||
| Amplitude (µV) | Group | Mean [SD] | ANOVA F(2,34) | Mean [SD] | ANOVA F(2,34) | Mean [SD] | ANOVA F(2,34) |
| Summed | Control | −5.36 [1.38] | 1.2 | 11.96 [3.05] | 0.8 | −10.55 [2.48] | 1.2 |
| NON | −5.05 [1.6] | 11.46 [3.73] | −9.82 [3.26] | ||||
| HON | −4.5 [1.08] | 10.44 [2.29] | −8.86 [2.16] | ||||
| Ring 1 | Control | −0.5 [0.16] | 2 | 1.24 [0.37] | 3.6 | −1.5 [0.39] | 7.8 ** |
| NON | −0.41 [0.11] | 1.10 [0.24] | −1.16 [0.36] | ||||
| HON | −0.4 [0.16] | 0.92 [0.23] | −0.97 [0.24] | ||||
| Ring 2 | Control | −1.05 [0.28] | 1.3 | −2.06 [0.44] | 2.4 | −2.06 [0.44] | 4 |
| NON | −1.01 [0.38] | −1.77 [0.64] | −1.77 [0.64] | ||||
| HON | −0.86 [0.24] | −1.51 [0.33] | −1.51 [0.33] | ||||
| Ring 3 | Control | −1.84 [0.57] | 2.3 | 4.09 [1.0] | 1.4 | −3.4 [0.68] | 2.2 |
| NON | −1.69 [0.53] | 3.89 [1.34] | −3.21 [1.15] | ||||
| HON | −1.40 [0.41] | 3.4 [0.67] | −2.7 [0.59] | ||||
| Ring 4 | Control | −2.02 [0.63] | 0.2 | 5.02 [1.49] | 0.2 | −4.52 [1.24] | 0.3 |
| NON | −2.00 [0.69] | 4.94 [1.58] | −4.35 [1.3] | ||||
| HON | −1.88 [0.53] | 4.62 [1.27] | −4.1 [1.29] | ||||
| Peak Time (ms) | Group | Median (Range) | KW | Median (Range) | KW | Median (Range) | KW |
| Summed | Control | 25 (5.0) | 4.9 | 45.42 (8.33) | 5 | 73.33 (9.17) | 0.1 |
| NON | 25 (7.5) | 43.33 (13.33) | 72.92 (10.0) | ||||
| HON | 24.17 (4.17) | 42.5 (6.67) | 73.33 (6.67) | ||||
| Ring 1 | Control | 27.08 (10.83) | 5.3 | 54.58 (11.67) | 3.2 | 75.83 (18.33) | 0.4 |
| NON | 25.83 (16.67) | 53.33 (19.17) | 75.42 (15.83) | ||||
| HON | 25.83 (9.17) | 52.5 (13.33) | 76.67 (16.67) | ||||
| Ring 2 | Control | 25.83 (6.67) | 7.8 | 49.58 (10.0) | 10.2 * | 73.33 (19.17) | 0.7 |
| NON | 25.42 (14.17) | 45.83 (15.83) | 72.92 (10.0) | ||||
| HON | 24.17 (4.17) | 43.33 (11.67) | 72.5 (20.0) | ||||
| Ring 3 | Control | 25 (5.0) | 5.9 | 44.58 (8.33) | 6.6 | 72.92 (15.83) | 0.4 |
| NON | 24.58 (7.5) | 43.33 (11.67) | 71.67 (15.0) | ||||
| HON | 23.33 (5.0) | 41.67 (8.33) | 73.33 (22.5) | ||||
| Ring 4 | Control | 25 (5.0) | 3 | 43.33 (9.17) | 2.4 | 70.42 (20.83) | 1.4 |
| NON | 24.17 (5.0) | 42.5 (9.17) | 70.83 (14.17) | ||||
| HON | 24.17 (4.17) | 41.67 (7.5) | 72.5 (11.67) |
N1 = first negative wave of multifocal pattern electroretinogram (mfPERG). P1 = positive wave of mfPERG. N2 = second negative wave of mfPERG. [SD] = Standard deviation. NON = multiple sclerosis without a history of optic neuritis; HON: multiple sclerosis with a history of optic neuritis. Groups were compared with respect to continuous variables (using analysis of variance (ANOVA) or Kruskal–Wallis test (KW) and a t-test, or Mann–Whitney U test). * p ≤ 0.05, ** p ≤ 0.01.