Table 3.
Outer and inner retinal layers thickness.
| Macula | Center | Parafoveal | Perifoveal | ||||
| Thickness (µm) | Group | Mean [SD] | ANOVA F(2,34) | Mean [SD] | ANOVA F(2,34) | Mean [SD] | ANOVA F(2,34) |
| Total | Control | 279.71 [25.63] | 0.2 | 344.43 [13.55] | 3.8 | 298.89 [9.66] | 1.4 |
| NON | 282.67 [27.77] | 337.48 [18.45] | 293.52 [13.32] | ||||
| HON | 286.73 [28.63] | 326.32 [17.1] | 290.75 [13.94] | ||||
| mRNFL | Control | 12.79 [2.75] | 0.3 | 21.95 [1.58] | 0.1 | 36.14 [2.65] | 3 |
| NON | 12.33 [3.06] | 22.04 [2.39] | 36.54 [5.9] | ||||
| HON | 13.18 [2.79] | 21.64 [2.13] | 32.05 [5.86] | ||||
| GCL | Control | 16.00 [5.11] | 0.2 | 51.75 [3.7] | 13.8 *** | 35.16 [2.8] | 6.5 ** |
| NON | 17.00 [8.5] | 48.21 [6.2] | 33.04 [2.9] | ||||
| HON | 18.09 [11.17] | 40.14 [6.7] | 30.73 [3.5] | ||||
| IPL | Control | 21.43 [4.3] | 0.2 | 41.84 [2.3] | 8.2 ** | 28.88 [1.9] | 3 |
| NON | 22.92 [6.9] | 39.46 [4.3] | 27.38 [2.8] | ||||
| HON | 22.73 [6.4] | 36.16 [3.8] | 26.55 [2.6] | ||||
| Control | 18.71 [4.63] | 0.2 | 46.79 [2.9] | 12 *** | 32.02 [2.32] | 4.9 * | |
| GCIPL | NON | 19.96 [7.65] | 43.83 [5.2] | 30.21 [2.76] | |||
| HON | 20.41 [8.72] | 38.15 [5.04] | 28.64 [3.02] | ||||
| INL | Control | 20.29 [6.91] | 1.3 | 40.82 [4.02] | 0.4 | 32.52 [1.88] | 0.4 |
| NON | 21.42 [7.33] | 39.6 [2.98] | 32.06 [2.66] | ||||
| HON | 25.64 [10.85] | 40.2 [2.4] | 32.84 [1.94] | ||||
| ONL | Control | 92.71 [8.84] | 0.4 | 71.25 [5.83] | 0.6 | 59.95 [5.37] | 1.6 |
| NON | 94.5 [15.22] | 68.23 [8.43] | 56.19 [5.74] | ||||
| HON | 89.18 [19.95] | 70.0 [6.16] | 58.25 [4.63] | ||||
| ORL | Control | 90.86 [2.28] | 0.5 | 81.77 [1.25] | 2.3 | 78.21 [1.28] | 2.7 |
| NON | 91.17 [3.35] | 83.38 [2.56] | 79.69 [1.75] | ||||
| HON | 89.55 [6.01] | 82.91 [2.0] | 79.48 [2.28] | ||||
| Optic disc | G | PMB | T | ||||
| Group | Mean [SD] | F(2,32) | Mean [SD] | F(2,32) | Mean [SD] | F(2,32) | |
| pRNFL | Control | 94.64 [5.84] | 2.4 | 54.33 [11.77] | 6.5 * | 71.42 [14.89] | 5.2 * |
| NON | 92.92 [11.41] | 45.0 [6.81] | 61.17 [10.97] | ||||
| HON | 86.18 [12.02] | 40.82 [8.3] | 55.18 [10.31] |
NON = multiple sclerosis without a history of optic neuritis; HON = multiple sclerosis with a history of optic neuritis; peripapillary retinal nerve fiber layer thickness: G = global average thickness, T = temporal, PMB = papillomacular bundle; mRNFL = macular retinal nerve fiber layer thickness; GCL = ganglion cell layer; IPL = inner plexiform layer; GCIPL = ganglion ell inner plexiform layer; INL = inner nuclear layer; ONL = Outer nuclear layer; ORL = Outer retinal layer; [SD] = standard deviation. Groups were compared with respect to continuous variables (using analysis of variance (ANOVA) and t-test).* p ≤ 0.05; ** p ≤ 0.01, *** p ≤ 0.001.