Table 1.

Extraction variables selected for Box-Bohnken Design (BBD) optimization.

Independent Variable	Factor Level			Dependent Variable	Goal
	−1	0	+1
Extraction temperature (°C) (P1)	40	50	60	Parthenolide yield (% w/w) (R)	Maximized
Extraction time (min) (P2)	35	45	55
Microwave power (W) (P3)	100	200	300