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. 2021 Mar 30;13(7):1584. doi: 10.3390/cancers13071584

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Wnt pathway negative regulator APC is a Schwann cell tumor suppressor gene and multiple pathways converge downstream resulting in Hippo/YAP activation. (A) Western blot showing loss of APC via CRISPR/Cas9 and increased YAP1 and CTNNB1 levels. (B) Loss of APC results in anchorage-independent growth and cell migration (1.5× magnification). (C) Loss of APC results is tumor formation in NRG xenograft model. (D) Diagram summarizing results showing overall Hippo/YAP activation via the loss of multiple tumor suppressor genes that occur in MPNSTs. Wnt, growth factor activity, cell density and Rho pathway(s) activation results in Hippo/YAP pathway activation in MPNSTs.