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. 2021 Mar 25;22(7):3367. doi: 10.3390/ijms22073367

Figure 8.

Figure 8

Schematic representation of the details of the experimental settings to the p65 pathway involved in the cellular senescence and proinflammatory paracrine transmission by small extracellular vesicles (sEV). (A) Proliferative mesenchymal stem cells (MSCs) (Non-Se) were treated with sEV from Se (DNA damage-induced senescence (DDIS) and therapy-induced senescence (TIS)) and the small inhibitors (JSH-23, MG-132 and curcumin) for six days. (B) MSCs were treated with sEV from proinflammatory-activated MSCs (tumor necrosis factor alpha (TNF-α)) and JSH-23, MG-132 and curcumin for six days.