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. 2021 Apr 2;22(7):3712. doi: 10.3390/ijms22073712

Figure 6.

Figure 6

Intrathecal TRPV1 antagonist pretreatment prevented BK- and OLDA-induced mechanical hypersensitivity. Administration of SB366791 (0.58 µg, i.t., n = 7), 15 min prior to co-administration of BK and OLDA, completely blocked mechanical allodynia examined with the von Frey filaments, with bending forces ranging from 10 mN to 59 mN (A), and hyperalgesia tested with forces from 80 mN to 370 mN (B). Data represent the mean ± S.E.M. of 7 (SB + BK + OLDA) and 6 (vehicle) independent experiments. The time of the i.t. administration is marked by arrows.