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. 2021 Apr 2;22(7):3712. doi: 10.3390/ijms22073712

Figure 7.

Figure 7

TRPV1 endogenous agonist i.t. treatment enhanced BK-induced mechanical allodynia and hyperalgesia. A detailed comparison of various treatment effects at 1 h and 2 h after the i.t. administration. (A,B) Co-administration of BK and OLDA evoked a similar allodynia as BK alone, 1 h after i.t. treatment. OLDA enhanced the allodynia 2 h after i.t. treatment. (C,D) Co-administration of BK and OLDA increased the mechanical hyperalgesia 2 h after i.t. treatment compared to BK alone. Data represent the mean ± S.E.M. with a scatterplot of the individual data points of 4–7 independent experiments. Statistical analysis: One-way ANOVA followed by Tukey’s test; ** p < 0.01, **** p < 0.0001, versus vehicle i.t. treatment; + p < 0.05, ++ p < 0.01, +++ p < 0.001, ++++ p < 0.0001, versus BK + OLDA i.t. treatment.