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(a) Inactivation of cyclin-dependent kinases (Cdks) by the Wee1/Mik1/Myt1 protein kinase family through the phosphorylation of T14 and Y15. (b) The promotion of the entrance of cell division cycle 25 A (Cdc25A) in the S-phase cell cycle through the activation of the Cdk2/CycE complex (on the right); the promotion of mitosis by Cdc25A-B-C through the activation of the Cdk1/CycB complex (on the left).
