Table 3.
IC50 values of the selected compounds for the inhibition of Cdc25 A, B, and C phosphatases.
| Cpd | Cdc25A (μM) | Cdc25B (μM) | Cdc25C (μM) |
|---|---|---|---|
| 798827 | 12.02 ± 1.03 | 16.73 ± 1.71 | 14.43 ± 1.33 |
| B8063 | 15.23 ± 1.37 | 18.03 ± 1.11 | 17.73 ± 1.36 |
| E7263 | >25 | >25 | >25 |
| E7887 | 7.41 ± 0.79 | 8.91 ± 1.02 | 8.12 ± 0.87 |
| F5312 | 17.12 ± 1.91 | 19.11 ± 1.88 | 19.34 ± 1.65 |
| G5918 | >25 | >25 | >25 |
| J3955 | 1.12 ± 0.09 | 2.19 ± 0.07 | 2.22 ± 0.07 |
| M6690 | 17.16 ± 1.14 | 19.83 ± 1.41 | 17.79 ± 1.83 |
| O0288000 | 12.03 ± 1.17 | 14.14 ± 1.51 | 12.93 ± 1.56 |
| PZ0191 | >25 | >25 | >25 |
| PZ0240 | 19.88 ± 2.07 | 22.13 ± 2.17 | 20.37 ± 2.34 |
| SML0701 | >25 | >25 | >25 |
| Menadione | 4.48 ± 0.17 | 5.97 ± 0.75 | 4.49 ± 0.27 |
All values are the mean ± S.D. of three independent determinations.