Table 4.

Acquired abnormal skin pigmentation related to DNA damage.

Pigment Change	Disease/Condition	Evidence for DNA Damage-Related	Reference
Hyper	UV-induced melanogenesis	Role of α-MSH secreted from UV-damaged keratinocytes in melanogenesis	[103,104]
Hypo	Leukotrichia	Associated with APE1 polymorphism	[112]