Table 4.
Sequence variation in P. falciparum sera5 in the non-repeat 2562 bp region. Nucleotide and amino acid positions are numbered after the P. falciparum 3D7 sequence. The number of isolates with variations are shown. Variations shared with previously reported P. falciparum sera5 sequences in PlasmoDB (https://plasmodb.org/plasmo/ accessed on 23 October 2020) and NCBI (https://www.ncbi.nlm.nih.gov/ accessed on 23 October 2020) databases are shown in bold font.
| (A) Non-synonymous change. | |||||||||||||||||||||||||||
| Nucleotide Position |
3 8 3 |
4 7 5 |
5 6 2 |
5 6 6 |
5 7 1 |
7 6 7 |
7 8 2 |
7 9 2 |
9 8 8 |
1 3 0 4 |
1
5 1 6 |
1 5 2 4 |
1 6 1 3 |
1 7 2 1 |
1 8 9 2 |
1 9 6 4 |
2
0 3 8 |
2 0 6 5 |
2 1 5 5 |
2 2 6 9 |
2 3 2 5 |
2
3 2 6 |
2 4 4 9 |
2 4 9 1 |
2 6 7 8 |
2 8 0 1 |
2 8 3 3 |
| Common | G | K | G | A | G | G | G | G | A | A | G | G | A | G | A | T | A | T | G | G | C | G | G | A | A | G | A |
| Variation | C | G | A | C | A | A | A | T | T | G | C | T | T | A | G | C | G | G | A | A | A | A | T | G | G | A | G |
| Amino Acid Position | 1 2 8 |
1 5 9 |
1 8 8 |
1 8 9 |
1
9 1 |
2 5 6 |
2 6 1 |
2 6 4 |
3
3 0 |
4 3 5 |
5
0 6 |
5 0 8 |
5 3 8 |
5 7 4 |
6 3 1 |
6 5 5 |
6
8 0 |
6 8 9 |
7 1 9 |
7 5 7 |
7 7 5 |
7
7 6 |
8 1 7 |
8 3 1 |
8 9 3 |
9 3 4 |
9 4 5 |
| Common | C | K | G | E | G | C | N | L | I | D | V | K | D | R | E | L | M | L | V | D | S | E | V | T | Q | R | K |
| Variation | S | E | S | A | S | Y | S | F | L | G | L | N | V | K | G | S | V | V | I | N | R | K | F | A | R | H | E |
| Malawi and Mozambique, n = 115 | 1 | - | - | - | 1 | 1 | - | - | 1 | 1 | 1 | 1 | - | 1 | 1 | 1 | 12 | - | 1 | 1 | - | 2 | 1 | 1 | 1 | - | - |
| eBL case, n = 63 | 1 | - | - | - | 1 | - | - | - | - | 1 | 1 | - | - | - | - | 1 | 6 | - | - | 1 | 1 | 1 | - | - | |||
| Control, n = 52 | - | - | - | - | - | 1 | - | - | 1 | - | - | 1 | - | 1 | 1 | - | 6 | - | 1 | 1 | - | 1 | 1 | - | - | - | - |
| Tanzania, n = 55 | - | 1 | 1 | - | 2 | - | 1 | - | 1 | - | - | - | 2 | - | - | - | 3 | - | - | - | 1 | - | - | - | - | 1 | 1 |
| Ghana, n = 33 | - | 1 | 1 | 1 | 1 | - | - | 1 | 1 | - | - | - | - | - | - | - | 4 | 1 | - | - | - | - | - | - | - | 1 | 1 |
| (B) Synonymous change. | |||||||||||||||||||||||||||
| Nucleotide Position | 5 6 4 |
7 7 7 |
7 9 2 |
9 0 3 |
1 2 2 1 |
1 5 9 0 |
1 6 0 2 |
1 7 4 9 |
1 9 2 3 |
2 1 0 6 |
2
3 4 6 |
2 8 8 2 |
2 6 3 1 |
||||||||||||||
| Common | T | A | T | A | T | T | A | T | T | A | T | T | A | ||||||||||||||
| Variation | G | G | C | G | C | C | G | G | C | G | C | C | G | ||||||||||||||
| Amino Acid Position | 1 8 8 |
2 5 9 |
2 6 4 |
3 0 1 |
4 0 7 |
5 3 0 |
5 3 4 |
5 8 3 |
6 4 1 |
7 0 2 |
7
8 2 |
7 9 4 |
8 7 7 |
||||||||||||||
| Amino Acid | G | G | L | E | S | D | P | S | S | G | Y | G | L | ||||||||||||||
| Malawi and Mozambique, n = 115 | 2 | 1 | - | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | ||||||||||||||
| eBL Case, n = 63 | 2 | 1 | - | 1 | 1 | 1 | - | 1 | - | - | 1 | 1 | - | ||||||||||||||
| Control, n = 52 | - | - | - | - | - | - | 1 | - | 1 | 1 | 1 | 1 | 1 | ||||||||||||||
| Tanzania, n = 55 | - | - | - | - | - | - | - | - | - | - | 1 | - | - | ||||||||||||||
| Ghana, n = 33 | - | - | 1 | - | - | - | - | - | - | - | - | - | - | ||||||||||||||