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. 2021 Apr 2;13(7):1690. doi: 10.3390/cancers13071690

Figure 8.

Figure 8

In vivo tracking and localization of ex vivo expanded CD4+T cells. Analysis of Tbet (A,B), RORγT (C,D) and FoxP3 (E,F) in CTV stained CD4+T cells injected on day of tumor-bearing wild-type mice. High salt expanded CD4+T cells for three stimulation cycles obtained from DLNs of wild type (A,C,E) and CD4+NFAT5-KO (B,D,F) were analyzed for tumor localization. (G,H) Th-phenotypic frequencies (G) and cytokine expression (H) of the tumor localized ex vivo expanded CD4+T cells obtained from high salt treated wild-type mice (magenta), high salt treated (purple), and equimolar mannitol treated CD4+NFAT5-KO mice (grey). Data obtained from n = 3 in each cohort and presented as mean ± SEM; (*) p < 0.05.