Table 2.

Review of the literature. Studies reporting margins based on MSTS classification.

Study	Margins	Sample Size	Histotypes	Tumor Grade	Median Follow Up (Months)	LR Rate	Other Prognostic Factors for LR?	Margin Indipendent Prognostic Factor for LR?	Homogeneous Cohort
Vodanovich et al. [37]	Radical/Wide Marginal/Intralesional	266	Infiltrative STS	High grade	85	13.0% 36.9%	yes	Age	yes
Cates et al. [28]	Radical/Wide Marginal Intralesional	166	All histotypes	High grade	51	12.0% 24.0% 50.0%	yes	-	no
Cates et al. [26]	Radical/Wide Marginal/Intralesional	166	All histotypes	High grade	49	11.0% (no RT) 3.0% (with RT) 100.0% (no RT) 35.0% (with RT)	yes	RT	no
Willeumier et al. [41]	Intralesional Marginal Wide	127	Infiltrative STS	High grade	71	50.0% 30.0% 8.0%	yes	Tumor size	yes

LR: local recurrence; RT: radiotherapy.