Table 3.

Review of the literature. Studies reporting margins based on AJCC classification.

Study	Margins	Sample Size	Histotypes	Tumor Grade	Median Follow Up (Months)	LR Rate	Margin Indipendent Prognostic Factor for LR?	Other Prognostic Factors for LR?	Homogeneous Cohort
Gundle et al. [29]	R0% R1 R2	2217	All Histotypes	All grades	65	6.0% 17.0% 38.0%	yes	Grade 3 Depth RT	no
Stojadinovic et al. [42]	R0% R1	2084	All histotypes	High- low grade	50	15.2% 28.0%	yes	Tumor size Histologic grade Retroperitoneal location Fibrosarcoma histologic subtype	no
Harati et al. [43]	R0 R1	643	All histotypes	All grades	64	32.9% 63.9%	yes	Age Histological grade Myxofibrosarcoma Adjuvant RT	no
Ahmad et al. [37]	R0% R1	382	All histotypes	All grades	82	7.0% 17.0%	yes	RT	no
Bilgeri et al. [35]	R0% R1	305	All Histotypes	Grade 2–3	60	17.0% 34.0%	yes	RT	no
Kainhofer et al. [31]	R0% R1	265	All histotypes	All grades	-	16.5% 36.7%	yes	Adjuvant ChT	no
Le Doussal et al. [44]	R0% R1	216	Infiltrative STS	All grades	42	37.0%	no	RT	no
Goertz et al. [45]	R0% R1/R2	192	Infiltrative STS	All grades	61	24.3% 50.9%	yes	Adjuvant RT	yes
Cates et al. [28]	R0% <1 mm ≥2 mm R1-R2	166	All histotypes	High grade	51	24.0% 12.0% 50.0%	yes	-	no
Cates et al. [26]	R0% R1	166	All histotypes	High grade	49	30.0% (no RT) 17.0% (with RT) 17.0% (with RT)	yes	RT	no
Iwata et al. [46]	R0% R1 R2	145	All histotypes	Grade 2–3	48	5.0% 21.0% 15.0%	yes	Histological infiltration	no
Sambri et al. [15]	R0% R1	129	Infiltrative STS	Grade 3	35	18.0% 29.4%	no	-	yes
Dadrass et al. [47]	R0% R1/R2	42	Infiltrative STS	All grades	-	13.0% 85.0%	yes	-	yes

LR: local recurrence; RT: radiotherapy; ChT: chemotherapy.