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. 2021 Apr 2;13(7):1687. doi: 10.3390/cancers13071687

Table 4.

Review of the literature. Studies reporting margins based on UICC classification.

Study Margins Sample Size Histotypes Tumor Grade Median Follow Up (Months) LR Rate Margin Indipendent Prognostic Factor for LR? Other Prognostic Factors for LR? Homogeneous Cohort
Gundle et al. [29] R0%
R1
R2
2217 All Histotypes All grades 65 6.0%
10.0%
38.0%
yes Grade 3
Depth
RT
no
Kainhofer et al. [31] R0%
R1
265 All histotypes All grades - 12.0%
57.9%
yes Adjuvant ChT
Tumor Depth
no
Fuiiwara et al. [48] R0%
R1
R2
109 All Histotypes Grade 1 67 7.0%
14.0%
54.0%
yes Tumor Depth no

LR: local recurrence; RT: radiotherapy; ChT: chemotherapy.