Table 1.

Rheumatic diseases and hereditary thrombophilia evolution during pregnancy.

Pathology	Evolution in Pregnancy	ANOs and Complications
SLE	Worsens	Miscarriage, foetal death, prematurity, IUGR, neonatal lupus, CHB, preeclampsia, and C-section.
RA	Improves in pregnancy, worsens in postpartum	Prematurity, IUGR, C-section, neonatal lupus, and CHB
SpA	Improves in pregnancy, worsens in postpartum	Prematurity, IUGR, and C-section
APS	Irrelevant, depends on aPL	Miscarriage, foetal death, prematurity, IUGR, preeclampsia, and C-section
SS	Irrelevant	Prematurity, IUGR, C-section, neonatal lupus, and CHB
UCTD	According to clinical status	Miscarriage, foetal death, prematurity, IUGR, neonatal lupus, CHB, preeclampsia, and C-section
HT	Irrelevant, depends on mutation	Miscarriage, foetal death, prematurity, IUGR, preeclampsia and C-section

Adverse neonatal outcomes (ANOs), rheumatic diseases (RD), hereditary thrombophilia (HT), systemic lupus erythematosus (SLE), intrauterine growth retarded (IUGR), Caesarean section (C-section), neonatal lupus, congenital heart block (CHB), rheumatoid arthritis (RA), spondyloarthritis (SpA), antiphospholipid syndrome (APS), antiphospholipid (aPL) antibodies, Sjögren syndrome (SS), undifferentiated connective tissue disease (UCTD). Taken from 6, 18.