Figure 3.

Schematic illustration of miRNA retargeting caused by editing of mature miRNAs. RNA editing can affect the miRNA-mediated modulation of gene expression by modifying the primary structure of wild-type (Wt) mature miRNAs. Such an event generates edited (Ed) miRNAs, often destroying their base-pairing with several complementary regions in the 3′UTRs of their original targets and creating complementarity for new targets. However, both the Wt and Ed miRNAs seem to share a subset of their target mRNAs.