Figure 5.

Binding pocket visualization of important bacterial potential enzyme targets docked with isolated compounds from Onosma chitralicum. (a,b) Compound 7 docked with M. tuberculosis beta-hydroxyacyl-ACP dehydratase HadAB, and bound in the same location, i.e., the channel at the dimer interface where the co-crystallized ligand fisetin was found in the pocket in the reported PDB. Compound 7 is shown in green stick representation and the dimeric protein with blue and green protomers. (c,d) Docked compound 6 (shown in red sticks) binds to the active site pocket of S. aureus tyrosyl-tRNA synthetase (in green ribbon).