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. 2021 Apr 3;26(7):2052. doi: 10.3390/molecules26072052

Table 10.

IC50 values were determined using a modification of the broth microdilution method and biodegradation determined by a closed bottle test by Ferlin et al. in 2013 [55]. The values of IC50 reported in the table are expressed in millimolar; TBABr and TBAOH·30H2O were studied as reference classical salts.

Compound Escherichia coli Bacillus subtilis Pseudomonas fluorescens Pseudomonas putida (CP1) Pseudomonas putida (KT2440) Biodegradation 1
TBABr 03.13–06.25 25.00–50.00 06.25–12.50 25.00–50.00 12.50–25.00 7.9
TBAOH·30H2O 06.25–12.50 12.50–25.00 12.50–25.00 12.50–25.00 12.50–25.00 3.8
TEABr --- --- --- --- --- 0
TMABr --- --- --- --- --- 2.6
196a 12.50–25.00 06.25–12.50 12.50–25.00 06.25–12.50 12.50–25.00 15.5
196b 06.25–12.50 03.13–06.25 03.13–06.25 03.13–06.25 12.50–25.00 15.5
196c 12.50–25.00 06.25–12.50 06.25–12.50 06.25–12.50 12.50–25.00 9.9
196d 12.50–25.00 03.13–06.25 12.50–25.00 06.25–12.50 12.50–25.00 Nd 2
196e 06.25–12.50 03.13–06.25 03.13–06.25 03.13–06.25 03.13–06.25 14.2
196f 12.50–25.00 06.25–12.50 06.25–12.50 06.25–12.50 12.50–25.00 12.2
52a 06.25–12.50 25.00–50.00 25.00–50.00 25.00–50.00 25.00–50.00 18.6
53a 12.50–25.00 25.00–50.00 25.00–50.00 25.00–50.00 25.00–50.00 22.8

1 ThOD: Theoretical oxygen demand; 2 Not determined due to the failing of the validation requirements for the test.