Table 1.
Selected liposomal formulations and lipid-based vaccines FDA approved for human use or in clinical trials for the treatment of infectious diseases.
| Commercial Name | Company | Active Compound | Lipid Composition | Indication |
|---|---|---|---|---|
| Ambisome® | Gilead Sciences/ Fujisawa Healthcare |
Amphotericin B | HSPC:DSPG:Chol | Fungal infections |
| Amphotec®/Amphocil® | Ben Venue Laboratories |
Amphotericin B | Cholesteryl sulfate | Fungal infections |
| Abelcet® | Sigma-Tau Pharmaceuticals |
Amphotericin B | DMPC:DMPG | Fungal infections |
| Epaxal® | Crucell | Formalin-inactivated Hepatitis A virus | DOPC:DOPE | Hepatitis A |
| Inflexal® | Crucell | Inactivated hemaglutinine of Influenza virus | DOPC:DOPE | Influenza |
| Arikayce® | Insmed, Inc. | Amikacin | DPPC:Chol | Mycobacterium avium complex (MAC) lung disease |
| Arikace TM | Transave, Inc. | Amikacin | DPPC:Chol | Pseudomonas aeruginosa infections (cystic fibrosis) |
| RTS,S/AS01 | GlaxoSmithKline | Recombinant fusion of P. falciparum circumsporozoite protein and Hepatitis B surface antigen |
MPL:DOPC:Chol | Malaria |
| ALIS | Insmed, Inc. | Amikacin | DPPC:Chol | Nontuberculous Mycobacterial lung infection |
| Vaxisome | NasVax | Inactivated Influenza virus | CCS | Influenza |
| JVRS-100 | Juvaris BioTherapeutics |
Inactivated Influenza virus | CLDC:Chol | Influenza |
| Nyotran | Aronex Pharmaceuticals |
Nystatin | DMPC:DMPG:Chol | Fungal infections |
| CAF01 | Statens Serum Institut |
Subunit protein antigen Ag85B-ESAT, DDA, TDB | DODAB:TDB | Tuberculosis |
| Vaxfectin | Vical | Plasmid DNA-encoded influenza proteins | VC1052:DPyPE | Influenza |
| MPER-656 Liposome Vaccine | National Institute of Allergy and Infectious Diseases (NIAID) | Immunogenicity of an HIV-1 gp41 MPER-656 | DOPC:DOPG | HIV infections |
DPPC, dipalmitoyl phosphatidyl choline; DSPG, distearoyl phosphatidyl glycerol; Chol, cholesterol; DOPE, dioleoyl phosphatidyl ethanolamine; HSPC, hydrogenated soybean phosphatidyl choline; DMPG, dimyristoyl phosphatidyl glycerol; DMPC, dimyristoyl phosphatidyl choline; DOPC, dioleoyl phosphatidyl choline; DOPG, dioleoyl phosphatidyl glycerol; DPPC, dipalmitoyl phosphatidyl choline; CCS, ceramide carbamoyl-spermine; MPL, monophosphoryl lipid A; CLDC, oleoyl oxy ethyl oleyl hydroxyethyl imidazolinium-chloride; DODAB, dioctadecyldimethyl ammonium bromide; TDB, trehalose 6,6′-dibehenate; VC1052, aminopropyl dimethyl tetradecenyloxy propanaminium bromide; DPyPE, diphytanoyl phosphatidyl ethanolamine.