Locus-specific motif enrichment and pathway analysis of differential DNA methylation. De novo motif enrichment and gene set enrichment analyses were performed using DMRs* based on location relative to known gene annotations, specifically examining the gene promoter (green), introns (yellow), and exons (grey). Locus-specific gene set enrichment of DMRs annotated to reside within A. Promoter, B. Intron, and C. Exon regions. *Q < 0.05, |Percent Methylation| > 25%.