Figure 15.

Upregulation of SHH and inverse correlation between miR205HG and SHH levels in EAC tissues. Tissues from 26 EAC patients that had already been tested for miR205HG expression were also tested for SHH expression by qRT-PCR. SHH expression was significantly upregulated relative to NE in the majority of EACs studied (23/26, average fold-change 154.7, paired t-test p-value < 0.0001). In addition, miR205HG and SHH expression levels were significantly inversely correlated (r = −0.73, p-value = 0.0001).