Table 2.

Top 11 tumor-suppressive lncRNA candidates are sorted by the highest NE/EAC fold change.

Gene Information	Normalized Copy Numbers										Fold Change
Name	NE1	BE1	EAC1	NE2	BE2	EAC2	NE3	BE3	NE4	BE4	NE/BE	NE/EAC	NE/BE	NE/EAC
CTA-55I10.1	1120	11	0	49	0	0	749	157	548	94	101.82	#DIV/0!	4.77	5.83
AC079305.1	270	8	60	11	17	3	76	13	52	16	33.75	4.5	5.85	3.25
NEAT1	41741	3557	12330	11208	29426	8631	47273	12815	32335	8864	11.73	3.39	3.69	3.65
RP11-206L10.11	20	3	7	10	42	22	28	14	38	25	6.67	2.86	2	1.52
CTC-228N24.3	99	6	38	16	34	8	34	27	32	10	16.5	2.61	1.26	3.2
NCRNA00275	664	28	294	15	38	3	120	44	88	28	23.71	2.26	2.73	3.14
SNHG12	240	33	113	13	11	5	49	24	53	18	7.27	2.12	5.04	2.94
SNHG5	1294	116	668	19	107	22	218	69	137	36	11.16	1.94	3.16	3.81
SNHG1	4665	657	2426	22	37	15	126	29	96	25	7.1	1.92	4.61	3.84
NBPF1	128	14	70	22	45	18	60	22	37	22	9.14	1.83	2.73	1.68
CTC-358I24.1	70	4	41	10	49	15	54	25	55	26	17.5	1.71	2.16	2.12
GAS5	3907	459	2302	30	64	17	219	90	160	66	8.51	1.7	2.43	2.42

RNAseq (RNA sequencing)-generated normalized copy numbers of two matched NE-BE-EAC paired tissues and two matched NE-BE paired tissues are shown above (NE: normal esophagus, BE: Barrett’s esophagus, EAC: esophageal adenocarcinoma). Top 11 tumor-suppressive lncRNA (long non-coding RNA) candidates are sorted by the highest NE/EAC fold change. We prioritized lncRNAs with the highest expression in NE (NE normalized copy number ≥ 10), which were sequentially downregulated during the NE-BE-EAC progression continuum (cut-off fold-change ≥ 1.5). Among 11 lncRNAs shown above, CTA-55I10.1 (subsequently re-named to miR205HG) had the highest NE/BE and NE/EAC fold changes.