Extended Data Fig. 7 ∣. Haematological parameters and atherosclerosis in Ldlr^−/− mice transplanted with Gsdmd^−/− bone marrow.

a, WBCs; b, lymphocytes (n = 14 Jak2^VF, n = 13 Jak2^VFGsdmd^−/− mice); c, monocytes (n = 14 Jak2^VF, n = 12 Jak2^VFGsdmd^−/− mice); d, neutrophils (n = 14 Jak2^VF, n = 13 Jak2^VFGsdmd^−/− mice); e, RBCs (n = 13 mice). f–h, Jak2^VF burden in blood lymphocytes (f), neutrophils (g), and monocytes (h; n = 14 Jak2^VF, n = 13 Jak2^VFGsdmd^−/− mice). i, Serum cholesterol (n = 13 mice). j, Representative H&E images of aortic root lesions from Ldlr^−/− mice with wild-type (WT) or Gsdmd^−/− bone marrow fed a WTD for 12 weeks. Dashed lines, necrotic core; scale bars 200 μm. k, Quantification of lesion area. l, Percentage necrotic core area (n = 12 wild-type, n = 14 Gsdmd^−/− mice). Mean ± s.e.m.; two-tailed t-test (a, b, d, e, i, k, l), two-tailed Mann–Whitney test (c, f–h).