Extended Data Fig. 3 ∣. Jak2^VF allele burden and blood cell counts in mice with Jak2^VF clonal haematopoiesis.

a, Experimental design for Jak2^VF clonal haematopoiesis mice. b–e, Fraction CD45.2:CD45.1 (Jak2^VF/control:CD45.1) in blood monocytes (b), all CD45⁺ cells (c), neutrophils (d), and lymphocytes (e); black arrow, induction of Mx1-cre (n = 10, 19, 18, 9, 20 control, n = 9, 18, 19, 9, 17 Jak2^VF mice, for day −7, 26, 40, 47, 53, respectively). f–, Blood cell counts of white blood cells (f; WBC), lymphocytes (g), monocytes (h), neutrophils (i), and red blood cells (j; RBCs) (n = 17, 19, 10, 21 control, n = 17, 16, 10, 13 Jak2^VF mice, for day −7, 26, 40, 53, respectively). k, Serum cholesterol (n = 17, 18, 19 control, n = 17, 12, 18 Jak2^VF mice, for day 26, 40, 53, respectively). l, Spleen weight (n = 19 mice). Mean ± s.e.m.; two-tailed Mann–Whitney test (l), two-way ANOVA followed by Bonferroni multiple comparison post hoc test (b–k).