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Roles of DDRs in matrix metalloproteinase (MMP) activation and invadosome formation.
| Receptor | MMP Activation/Invadosome Formation | Cancers |
|---|---|---|
| DDR1 | Increase | -Lung carcinoma [82] -Pituitary adenoma [83] -Colorectal carcinoma [84] -Renal carcinoma [85] -Pancreatic [86] -Liver [87] -Breast carcinoma [24] |
| Decrease | ||
| DDR2 | Increase | -Ovarian [32] -Melanoma [62]-Hepatocellular carcinoma [89] -Breast [90] |
| Decrease |
