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. 2021 Apr 6;22(7):3776. doi: 10.3390/ijms22073776

Table 1.

Glycosphingolipid (GSL) markers useful for cell identification.

GSL/Antigen
Structure		 Major Expressing Cell or Expressing Cancers Ref.
Gb3Cer/CD77
Galα1,4Galβ1,4Glcβ1,1Cer		 Burkitt lymphoma [16]
Gb4Cer/blood group P antigen
GalNAcβ1,3Galα1,4Galβ1,4Glcβ1,1Cer		 Erythrocytes [17]
Gb5Cer/SSEA-3
Galβ1,3GalNAcβ1,3Galα1,4Galβ1,4Glcβ1,1Cer		 Stem cells/iPS cells [18]
Sialyl-Gb5Cer/SSEA-4
Siaα2,3Galβ1,3GalNAcβ1,3Galα1,4Galβ1,4Glcβ1,1Cer		 Stem cells/iPS cells [18]
Fucosyl-Gb5Cer/Globo-H
Fucα1,2Galβ1,3GalNAcβ1,3Galα1,4Galβ1,4Glcβ1,1Cer		 Breast and other cancers [19,20]
Sialyl Lewisa/CA19-9-terminated GSL
Siaα2,3Galβ1,3(Fucα1,4)GlcNAcβ1,3Galβ1,4Glcβ1,1Cer		 Gastrointestinal cancer [21,22]
GD3
Siaα2,8Siaα2,3Galβ1,4Glcβ1,1Cer		 Melanoma [23]
Gg4Cer (asialo-GM1)
Galβ1,3GalNAcβ1,4Galβ1,4Glcβ1,1Cer		 Natural killer cells [24,25]

Major GSL antigens used to identify human cells are shown. Abbreviations: Cer, ceramide; Fuc, fucose; Gal, galactose; GalNAc, N-acetylgalactosamine; Glc, glucose; GlcNAc, N-acetylglucosamine; Sia, sialic acid.