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. 2021 Apr 6;13(7):1721. doi: 10.3390/cancers13071721

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inflammation is a distinctive feature in liver tumors associated with lipid-enriched and cholesterol diet consumption. (A) Gene set enrichment analysis (GSEA) of hallmark IL6-Jak-STAT3 signaling, data set comparing W/DEN and HC/DEN to CW/DEN (n = 4). (B) Process networks analysis related to inflammation in tumors from CW/DEN (black), W/DEN (red) and HC/DEN (blue) (n = 4). The top rank-ordered processes and networks are based on statistical significance (p < 0.01). (C) Macrophages infiltration by immunofluorescence of F4/80 (green fluorescence) and CD206 (M2 phenotype, red fluorescence), representative images of four animals per group, original magnification, 100X. Quantification of F4/80 and CD206 fluorescence. (D) Proinflammatory cytokines serum concentration of all mice groups. Proteins were determined by based multiplex immunoassay (n = 4). Each bar represents the average ± SEM ** p < 0.01 vs. CW group; # p < 0.05 vs. W diet alone group.

Inflammation is a distinctive feature in liver tumors associated with lipid-enriched and cholesterol diet consumption. (A) Gene set enrichment analysis (GSEA) of hallmark IL6-Jak-STAT3 signaling, data set comparing W/DEN and HC/DEN to CW/DEN (n = 4). (B) Process networks analysis related to inflammation in tumors from CW/DEN (black), W/DEN (red) and HC/DEN (blue) (n = 4). The top rank-ordered processes and networks are based on statistical significance (p < 0.01). (C) Macrophages infiltration by immunofluorescence of F4/80 (green fluorescence) and CD206 (M2 phenotype, red fluorescence), representative images of four animals per group, original magnification, 100X. Quantification of F4/80 and CD206 fluorescence. (D) Proinflammatory cytokines serum concentration of all mice groups. Proteins were determined by based multiplex immunoassay (n = 4). Each bar represents the average ± SEM ** p < 0.01 vs. CW group; # p < 0.05 vs. W diet alone group.