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. 2021 Apr 6;13(7):1721. doi: 10.3390/cancers13071721

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lipid-associated four-gene signature defines a subtype of human liver cancer with a poor prognosis. (A) Plots chart showing higher expression of Slc41a3, Fabp5, Igdcc4 and Mthfd1l in human HCC (n = 371) compared to no-tumor liver tissue (NL, n = 50) according to the TCGA database (https://www.cbioportal.org/, accessed on 10 November 2020). TPM, transcripts per million. * p < 0.01 vs. normal liver (NL). (B) Kaplan–Meier curves of overall survival in HCC patients. Patients with HCC were separated into two groups, high (red) and low (black) expression of Slc41a3 (p = 0.0138), Fabp5 (p = 0.0005), Igdcc4 (p = 0.0010), and Mthfd1l (p = 0.0328). (C) HCC data set from the TCGA was divided into unaltered and altered groups regarding the four-gene signature, and the overall survival in HCC patients was addressed and plotted in a Kaplan–Meier curve (altered red group) and low (unaltered black group).

Lipid-associated four-gene signature defines a subtype of human liver cancer with a poor prognosis. (A) Plots chart showing higher expression of Slc41a3, Fabp5, Igdcc4 and Mthfd1l in human HCC (n = 371) compared to no-tumor liver tissue (NL, n = 50) according to the TCGA database (https://www.cbioportal.org/, accessed on 10 November 2020). TPM, transcripts per million. * p < 0.01 vs. normal liver (NL). (B) Kaplan–Meier curves of overall survival in HCC patients. Patients with HCC were separated into two groups, high (red) and low (black) expression of Slc41a3 (p = 0.0138), Fabp5 (p = 0.0005), Igdcc4 (p = 0.0010), and Mthfd1l (p = 0.0328). (C) HCC data set from the TCGA was divided into unaltered and altered groups regarding the four-gene signature, and the overall survival in HCC patients was addressed and plotted in a Kaplan–Meier curve (altered red group) and low (unaltered black group).