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. 2021 Apr 6;26(7):2095. doi: 10.3390/molecules26072095

Table 2.

Effects and applications of caffeine established by the EFSA scientific opinion and the scientific evidence and criteria provided by the literature and International Institutions.

Types of Caffeine Sports Involved Dose Ergogenic Effects
EFSA Scientific opinion
EFSA [11] Does not specify type of caffeine. Endurance sports. Minimum 70 mg/dose of product.
3 mg/kg body weight (200 mg approximately), 1 h before physical exercise.
* 4 mg/kg body weight to reduce the perception of effort during exercise.
Increases endurance performance.
Increases resistance capacity.
Reduces the perception of effort during exercise.
Scientific evidence
IOC [1] Anhydrous caffeine
(pills or powder).
Endurance sports, intermittent sports, and short-term sprints sports. 3–6 mg/kg body weight, 60 min before exercise.

>3 mg/kg body weight before or during exercise, accompanied by a source of CHO.
Improves neuromuscular function.
Heightens the state of vigilance and alertness.
Reduces the perception of effort during exercise.
AIS [17] Caffeine. Endurance sports, team/intermittent sports, high intensity physical activity of short duration. At 1–3 mg/kg body weight, benefits are observed.

At >6–9 mg/kg body weight, there are no benefits. *
Directly contributes to optimal performance.
Stimulates the CNS.
Decreases the perception of effort during exercise.
* Variability between subjects *
AND [10] Does not specify the type of caffeine. In its bibliographic references:
endurance sports, intermittent sports, or team sports.
3–6 mg/kg body weight. Acts on the CNS, reducing the perception of fatigue.
Promotes the release of Ca2+ in the endoplasmic reticulum of skeletal muscle.
Systematic review and meta-analysis [21] Caffeine. Endurance sports. 3–6 mg/kg body weight. Improves sports performance.
Systematic review and meta-analysis [23] Caffeine (capsule or liquid form). Sports of muscular strength and power (vertical jumps). 0.9–7 mg/kg body weight. Improves sports performance through greater application of muscle strength and power.
A meta-analysis [24] Caffeine (capsule or beverage form). Endurance sports. 3–6 mg/kg body weight Improvement of sports performance (higher concentrations of blood glucose and blood lactate and lower perception of effort during exercise).
Systematic review and meta-analysis [22] Caffeine
(any dose and form).
Strength sports 1–9 mg/kg body weight or 150–328 mg Improves the speed of movement in strength exercises, with medium and moderately high loads

EFSA: European Food Safety Authority; AND: Academy of Nutrition and Dietetics; AIS: Australian Institute of Sport; IOC: International Olympic Committee; CNS: Central Nervous System; Source: Own elaboration based on data collected from different institutions.