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. 2021 Apr 6;22(7):3779. doi: 10.3390/ijms22073779

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Predicted amino acid sequences from 7TM C-terminal variants (modified from [17]. The top panel is an animation that shows structures of MORs and adjacent proteins on membrane. TM domains are indicated by cylinders. Splice junctions are shown by arrows. Calcium (Ca++) and potassium (K+) channels are indicated by opened canals across membrane. Gα, Gβ and Gγ: G proteins; PLCβ: phospholipase Cβ; PLA2: phospholipase A2; The bottom panel listed predicted amino acid sequences encoded by downstream exons of exon 3 in mouse (mMOR), rat (rMOR) and human (hMOR) splice variants. Italic red S, T and Y are predicted phosphorylation sites. Underlined sequences are predicted phosphorylation codes, PxPxxE/D or PxxPxxE/D, for β-arrestin binding based on crystal G protein coupled receptors (GPCR) structures [72].