Figure 1. Effect of α-methyltryptophan (the dl-enantiomeric mixture and the individual d- and l-isomers) on body weight in wild type and Slc6a14-null male mice.
(A) Body weight gain in wild type (WT) male and Slc6a14y/− male mice on a normal diet (ND) and a high-fat diet (HFD) for 3 months. (B) Body weight gain measured in wild type male mice on HFD without treatment (Control) or exposed to α-methyl-dl-tryptophan (α-MT, 2 mg/ml in drinking water) ad libitum for a week. (C) HFD-fed male Slc6a14y/− mice were exposed either to drinking water (Control) or α-methyl-d-tryptophan (α-MDT; 1 mg/ml) or α-methyl-L-tryptophan (α-MLT; 1 mg/ml) ad libitum for a week. At the end of the experiment, gain/loss in body weight was monitored. Data are means ± S. E. M (N = 5 mice/group). ** P < 0.01; *** P < 0.001.