Figure 2. Weight-loss effect of α-MLT in wild type mice fed a normal diet or a high-fat diet and the consequences of the treatment on blood glucose and serum leptin levels.

Wild type mice (males) fed with ND (A,C) or HFD (B,D) were subjected to drinking water alone or to α-MLT (1 mg/ml) in drinking water. The body weight was measured twice a week (A,B). At end of the 4-week period, blood was collected after 4 h fasting to measure blood glucose and leptin levels (C,D). Data are means ± S. E. M (N = 5 mice/group). ** P < 0.01; *** P < 0.001; a, P < 0.001 compared with body weight in untreated control; b, P < 0.001 compared with body weight at the time of drug withdrawal.