Table 1. Effect of α-MLT treatment (1 mg/ml in drinking water for 4 weeks) on serum lipid profile, kidney function and liver function in wild type mice on the high-fat diet.
Control | Treated | P value | |
---|---|---|---|
Lipid profile | |||
Cholesterol (mg/dl) | 145 ± 4 | 106 ± 3 | 0.0001 |
Triglycerides (mg/dl) | 73 ± 5 | 97 ± 17 | 0.1 |
Kidney function | |||
BUN (mg/dl) | 28.6 ± 2.9 | 34.2 ± 2.6 | 0.1 |
Creatinine (mg/dl) | 0.25 ± 0.03 | 0.30 ± 0.04 | 0.2 |
Liver function | |||
Total protein (g/dl) | 4.78 ± 0.09 | 4.25 ± 0.06 | 0.001 |
Albumin (g/dl) | 2.25 ± 0.05 | 1.90 ± 0.04 | 0.001 |
Globulin (g/dl) | 2.53 ± 0.05 | 2.35 ± 0.09 | 0.06 |
AST (U/I) | 70.5 ± 7.0 | 79.5 ± 16.3 | 0.32 |
Total bilirubin (mg/dl) | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.56 |
Values are means ± S.E.M (N = 5 mice/group).
At the end of the treatment period, blood was collected from control (i.e. untreated) and treated mice to prepare serum, which was used for analysis.