Table 2. Plasma concentration of amino acids in high-fat diet (HFD)-fed C57BL/6 mice and normal diet (ND)-fed ob/ob mice with and without α-MLT treatment.

Amino acids	WT-HFD	WT-HFD-α-MLT	P value	ob/ob-ND	ob/ob-ND-α-MLT	P value
Taurine	519.08 ± 32	506.98 ± 22	0.280	878.32 ± 118	610.13 ± 40	0.010
Aspartic acid	15.78 ± 2	15.06 ± 2	0.294	19.88 ± 4	8.13 ± 1	0.004
Threonine	302.73 ± 70	284.15 ± 10	0.309	185.88 ± 30	196.92 ± 11	0.292
Serine	182.91 ± 25	150.56 ± 8	0.025	186.45 ± 46	123.75 ± 6	0.041
Asparagine	68.54 ± 13	48.18 ± 9	0.214	87.02 ± 37	39.78 ± 4	0.018
Glutamine	767.74 ± 50	712.05 ± 32	0.063	853.17 ± 179	669.6 ± 32	0.013
Glycine	210.49 ± 35	144.63 ± 14	0.006	206.88 ± 54	140.7 ± 8	0.050
Alanine	502.99 ± 55	468.31 ± 67	0.227	721.18 ± 194	466.4 ± 15	0.043
Citrulline	60.63 ± 12	56.4 ± 6	0.272	73.37 ± 10	82.73 ± 9	0.151
Valine	318.23 ± 50	304.66 ± 27	0.323	249.57 ± 45	216.97 ± 28	0.174
Methionine	102.63 ± 30	98.7 ± 27	0.426	85.18 ± 10	87.06 ± 26	0.456
Isoleucine	115.98 ± 13	104.25 ± 8	0.092	104.38 ± 23	78.42 ± 13	0.085
Leucine	168.20 ± 23	163.15 ± 15	0.364	278.42 ± 45	224.92 ± 34	0.088
Tyrosine	103.3 ± 22	120.39 ± 17	0.132	121.65 ± 9	94.68 ± 25	0.074
Phenylalanine	88.35 ± 3	89.86 ± 15	0.426	132.85 ± 9	108.9 ± 15	0.041
Ornithine	115.44 ± 25	48.9 ± 2	0.001	172.83 ± 23	97.75 ± 22	0.007
Lysine	446.44 ± 66	402.98 ± 29	0.135	289.35 ± 62	306.73 ± 52	0.364
1-Methylhistidine	4.65 ± 0.5	4.23 ± 0.5	0.099	6.77 ± 1.6	8.71 ± 1.4	0.096
Histidine	87.23 ± 4	88.04 ± 4	0.394	97.55 ± 10	90.4 ± 10	0.209
Tryptophan	112.60 ± 12	6.06 ± 12	0.000	121.72 ± 15	24.53 ± 29	0.003
Arginine	71.64 ± 38	124.36 ± 12	0.018	46.73 ± 7	94.42 ± 20	0.008
Proline	180.41 ± 57	173.99 ± 17	0.419	194.62 ± 33	137.93 ± 19	0.031

Values are given as nmoles/ml (μM) in plasma (means ± S.D; 3 mice/group).