Table 5. Examples of T-cell hematologic malignancy-related possible therapy-associated cutaneous tumor lysis syndrome.

CD8, cluster of differentiation 8; PCAEC, primary cutaneous aggressive epidermotropic cytotoxic; Ref, reference; yo, year old; +, positive

Patients	Tumor	Comments	Ref
Three of 50 patients	Mycosis fungoides	In a study of 50 patients with primary and recurrent mycosis fungoides, only eight of the 14 patients who had either erythroderma and/or ulcerated lesions on initial presentation developed “severe moist desquamation” during total skin electron irradiation; three of the 50 patients were hospitalized due to possible therapy-associated cutaneous lysis syndrome appearing as ulceration and skin infection	[27]
50 yo man	Mycosis fungoides	A man with only cutaneous tumor stage mycosis fungoides developed painful extensive necrosis of the lymphoma lesions, compatible with possible therapy-associated cutaneous tumor lysis syndrome, 18 weeks after beginning treatment with bexarotene, vorinostat, and high-dose fenofibrate	[42]
45 yo man	CD8+ mycosis fungoides	A man with hypopigmented CD8+ mycosis fungoides and possible therapy-associated cutaneous tumor lysis syndrome who developed central necrosis of existing lesions and new lesions that would ulcerate after initiating treatment with systemic retinoids (either etretinate or acitretin) and subcutaneous interferon alpha-2b	[41]
68 yo man	CD8+ PCAEC T-cell lymphoma	A man with CD8+ PCAEC T-cell lymphoma developed therapy-associated ulceration and necrosis of the new skin lesions compatible with possible therapy-associated cutaneous lysis syndrome after methotrexate was started	[40]