Table 3. Objectives and Potential Therapeutic Targets.

CTHRC1: collagen triple helix repeat containing 1, DDR2: discoidin domain receptor 2, EGFR: epidermal growth factor receptor, TGFβ: transforming growth factor-β

Authors	Year of publication	Purpose of the study	Potential therapeutic target
Li et al. [23]	2020	To investigate the role of anticancer gene miR-30b-3p on the biological activity of ovarian cancer cells and its association with the CTHRC1 gene	MicroRNA miR-30 family
Wahab et al. [24]	2020	To study the effect of differential expression of microRNAs and their target genes in ovarian cancer growth, migration, and invasion	MicroRNA
Price et al. [27]	2020	To assess the effect of NOTCH3 signaling on tumor cell adhesion to the peritoneum, tumor cell proliferation, and patient survival	NOTCH3
Grither et al. [13]	2018	To study the TWIST1 induced expression of DDR2 leading to mesothelial cell clearance and tumor cell invasion	DDR2
Guo et al. [12]	2017	To investigate the role of CTHRC1 in ovarian cancer cell migration, invasion, and adhesion to vitronectin, peritoneal metastasis, and metastasis to distant organs	CTHRC1, Integrin β3/FAK signaling
Chan et al. [25]	2016	To elucidate the mechanistic role of tumor suppressor microRNAs in ovarian cancer invasion and cancer cell physical properties	MicroRNA
Ye et al. [26]	2016	To study the effect of CTHRC1 induced EGFR signaling on ovarian cancer cell migration and invasion	CTHRC1
Cheon et al. [15]	2014	To identify collagen remodeling genes regulated by TGFβ signaling, promoting metastasis and leading to poor clinical outcome	Collagen remodeling genes, e.g., COL11A1