Table 4. Objectives and Potential Therapeutic Targets.
uPAR-FPR1: urokinase plasminogen activator receptor-formyl peptide receptor 1, AAM: alternatively activated macrophages, MCA: multicellular aggregates, TGFβ: transforming growth factor-β, HDAC4: histone deacetylase 4, MAPK7: mitogen-activated protein kinase 7, PAK2: p21 activated kinase 2, CSE: chondroitin sulfate E
| Authors | Year of publication | Purpose of the study | Potential therapeutic target |
| Minopoli et al. [14] | 2019 | To illustrate the role of FPR1 in adhesion to mesothelial cell layer and vitronectin leading to invasion of ovarian cancer cells | Inhibition of uPAR-FPR1 interaction |
| Fogg et al. [7] | 2019 | To identify the role of soluble factors secreted from AAM in spheroid spreading across the ECM | JAK/STAT3/MMP-9 pathway |
| Klymenko et al. [29] | 2018 | To study the effect of ascites induced compression on invasion, lateral dispersion, the proliferation of cells of MCA | Drugs to eliminate ascites |
| Klymenko et al. [30] | 2017 | To study the diverse cadherin expression affecting the behavior of ovarian cancer MCA and single-cell dissemination | Cadherin |
| Choi et al. [31] | 2016 | To assess the effect of loss of E-cadherin on inclusion cyst formation and collective cancer cell migration | Cadherin, miR-200, TGFβ signaling |
| Shen et al. [17] | 2016 | To elucidate the mechanism of action of HDAC4 on ovarian cancer cell proliferation and migration via repression of p21 | Nuclear HDAC4 |
| Dai et al. [8] | 2015 | To study the role of MAPK7 on ovarian cancer cell proliferation, migration, invasion | Inhibition of MAPK7 |
| Flate and Stalvey [28] | 2014 | To demonstrate the role of PAK2 mediating the ovarian cancer cells interaction with collagen type I and fibronectin, causing metastasis | Inhibition of PAK2 |
| Pettee et al. [32] | 2014 | To study the effect of multiple Rho-GTPase effectors (mDia2, ROCK) on ovarian cancer cell invasion | mDia2/ROCK signaling axis |
| Vallen et al. [33] | 2014 | To study the mechanistic role of CSE in providing adhesiveness to tumor cells forming spheroids and cell migration | Chondroitin sulfate E (CSE) rich motifs |