Table 1.
Prediction of potential organ-related side-effects
| Gene ID | Gastrointestinal tract | Genitourinary tissues and organs | CNS | Respiratory tract | Endocrine tissues | Immune tissues and cells | Other tissues/organs |
|---|---|---|---|---|---|---|---|
| ADA | Appendix, duodenum, small intestine, stomach | − | − | − | − | Lymph nodes, dendritic cells, monocytes, NK cells, spleen, T cells, tonsil | Adipose tissue |
| ADAM33 | Appendix, colon, esophagus, liver, small intestine, stomach | Kidney, endometrium, epididymis, fallopian tube, gall-bladder, ovary, prostate, seminal vesicle, testis, urinary bladder, uterine cervix, vagina | Cerebral cortex | − | Adrenal gland | Spleen, tonsil | Adipose tissue, breast, placenta, smooth muscle |
| ADCY7 | Appendix, esophagus, oral mucosa, pancreas | Kidney, gall-bladder, ovary, seminal vesicle, urinary bladder, uterine cervix, vagina | Cerebellum | Lung | − | Spleen, tonsil | Heart muscle, placenta, skin |
| AKR1A1 | Appendix, colon, duodenum, esophagus, liver, pancreas, rectum, small intestine, stomach, salivary gland | Kidney, endometrium, epididymis, fallopian tube, gall-bladder, ovary, prostate, seminal vesicle, testis, urinary bladder, uterine cervix, vagina | Amygdala, basal ganglia, cerebellum, cerebral cortex, hippocampus, hypothalamus, midbrain, spinal cord | Bronchus, lung, nasopharynx | Adrenal gland, parathyroid gland, pituitary gland, thyroid gland | Bone marrow, b-cells, dendritic cells, granulocytes, lymph node, monocytes, NK cells, spleen, T cells, tonsil | Adipose tissue, breast, heart muscle, placenta, skeletal muscle, skin, smooth muscle |
| B3GNT3 | Colon, duodenum, esophagus, rectum, small intestine, stomach, salivary gland | Kidney, gall-bladder, urinary bladder | − | − | − | − | Placenta |
| CA12 | Appendix, colon, esophagus, oral mucosa, pancreas, rectum, salivary gland | Kidney, endometrium, fallopian tube, urinary bladder, uterine cervix, vagina | Basal ganglia | − | − | − | Breast, skin, smooth muscle |
| CACNA1H | Colon, esophagus | Endometrium, fallopian tube, gall-bladder, ovary, prostate, seminal vesicle, testis, urinary bladder, uterine cervix | − | Lung, nasopharynx | Adrenal gland, pituitary gland, thyroid gland | − | Skeletal muscle, smooth muscle, soft tissue |
| CD83 | Appendix | Kidney, gall-bladder, ovary, seminal vesicle, uterine cervix, vagina | Cerebellum, cerebral cortex | Lung | Adrenal gland | Bone marrow, B-cells, lymph node, monocytes, spleen, tonsil | − |
| CEACAM6 | Appendix, colon, duodenum, esophagus, rectum, small intestine, salivary gland | Gall-bladder, urinary bladder, uterine cervix, vagina | − | Lung | − | Bone marrow, tonsil | − |
| CX3CR1 | Appendix, colon, duodenum, rectum, small intestine | Kidney, gall-bladder, seminal vesicle, testis | Caudate, cerebral cortex | Lung | Adrenal gland | Dendritic cells, tonsil | Breast, placenta, skin, soft tissue |
| EFNA4 | − | − | − | − | − | B cells, dendritic cells | Skin |
| ENPP1 | Liver, pancreas, stomach | Kidney, endometrium, gall-bladder, testis | − | − | Parathyroid gland, thyroid gland | − | Placenta, skin, smooth muscle |
| ERBB2 | Appendix, colon, duodenum, esophagus, liver, pancreas, rectum, small intestine, stomach, salivary gland | Kidney, endometrium, epididymis, fallopian tube, gall-bladder, ovary, prostate, seminal vesicle, testis, urinary bladder, uterine cervix, vagina | − | Bronchus, lung, nasopharynx | Parathyroid gland, pituitary gland, thyroid gland | Tonsil | Breast, heart muscle, placenta, skeletal muscle, skin, smooth muscle |
| FGFR4 | Appendix, colon, duodenum, liver, pancreas, rectum, small intestine, stomach | Kidney, gall-bladder, ovary, seminal vesicle, testis, urinary bladder | − | Lung, nasopharynx | Adrenal gland | Spleen | − |
| GFRA1 | Appendix, colon, duodenum, liver, rectum, small intestine | Kidney, endometrium, epididymis, fallopian tube, gall-bladder, prostate, testis | − | − | − | Tonsil | Breast, heart muscle, placenta, skeletal muscle, smooth muscle |
| GPR84 | Appendix | − | Caudate, cerebellum | − | − | Bone marrow | − |
| GPRC5A | Colon, duodenum, esophagus, rectum, small intestine, stomach, salivary gland | Kidney, gall-bladder, ovary, urinary bladder, uterine cervix, vagina | Caudate, hippocampus | Lung | Thyroid gland | − | Adipose tissue, placenta |
| HRH1 | Colon, rectum | Kidney, gall-bladder | − | − | − | − | Smooth muscle |
| ITGB6 | Appendix, colon, duodenum, rectum, small intestine, stomach | Kidney, gall-bladder, urinary bladder | − | Lung | Adrenal gland, parathyroid gland | Tonsil | Breast, heart muscle, skeletal muscle |
| ITPR1 | − | Endometrium, epididymis, fallopian tube, gall-bladder, ovary, prostate, seminal vesicle | Caudate, cerebellum, cerebral cortex, hippocampus | − | Adrenal gland, parathyroid gland, thyroid gland | − | Breast, smooth muscle |
| KCNJ11 | Liver, pancreas | Prostate, testis | Cerebellum | − | − | − | Skeletal muscle, soft tissue |
| LRIG1 | Colon, duodenum, pancreas, stomach | Kidney, endometrium, fallopian tube, gall-bladder, prostate, testis, uterine cervix | Basal ganglia, cerebellum, cerebral cortex, hippocampus | Bronchus | − | − | Adipose tissue, beast, placenta, smooth muscle, soft tissue |
| MUC16 | − | Endometrium, fallopian tube, uterine cervix | − | Bronchus, nasopharynx | − | − | − |
| PRRT3 | − | Kidney | Caudate, cerebellum, cerebral cortex | − | Adrenal gland, parathyroid gland | Tonsil | − |
| PTGER3 | − | Kidney, endometrium, uterine cervix | − | − | − | Granulocytes | Adipose tissue, breast, smooth muscle |
| PTPRT | Duodenum, oral mucosa, rectum, stomach | Fallopian tube, gall-bladder, seminal vesicle, testis | Caudate, cerebellum, cerebral cortex, hippocampus | − | − | − | Soft tissue |
| SCUBE2 | Appendix, duodenum, liver, small intestine, stomach | Kidney, endometrium, epididymis, fallopian tube, gall-bladder, prostate, testis, urinary bladder, uterine cervix | Caudate | − | Parathyroid gland | Tonsil | Adipose tissue, breast, placenta, skin, smooth muscle |
| SLC16A6 | Colon, liver, rectum, small intestine, salivary gland | Kidney, epididymis, fallopian tube, ovary, testis | Cerebellum | − | Adrenal gland | − | Heart muscle |
| SLC23A1 | Colon, duodenum, small intestine | Kidney, fallopian tube | − | − | − | − | − |
| SLC4A5 | Appendix, colon, duodenum, rectum, small intestine, stomach | Kidney, epididymis, fallopian tube, gall-bladder, seminal vesicle, testis, urinary bladder | − | − | Thyroid gland | − | Breast |
| SPNS2 | Duodenum, esophagus, small intestine, stomach | Kidney, gall-bladder, ovary, uterine cervix, vagina | Cerebral cortex, spinal cord | Lung | − | Bone marrow | Adipose tissue, skin |
| SUSD3 | Appendix, small intestine | Kidney, endometrium, fallopian tube, ovary, testis, uterine cervix | Caudate, cerebellum, cerebral cortex, hippocampus | Nasopharynx | Adrenal gland | Bone marrow, B cells, dendritic cells, granulocytes, lymph node, spleen, T cells, tonsil | Adipose tissue, breast, heart muscle, skin, soft tissue |
| TMEM132A | Appendix, esophagus, stomach, salivary gland | Endometrium, ovary, uterine cervix | Amygdala, basal ganglia, cerebellum, cerebral cortex, hippocampus, hypothalamus, midbrain, spinal cord | Bronchus | Adrenal gland, pituitary gland | − | Placenta, skeletal muscle |
| TMEM71 | Appendix, colon, duodenum, pancreas, pancreas, rectum, small intestine, stomach, salivary gland | Kidney, endometrium, gall-bladder, testis | Caudate | Bronchus | Adrenal gland, thyroid gland | Bone marrow, dendritic cells, granulocytes, lymph node, monocytes, NK cells, spleen, T cells | Hear muscle, soft tissue |
| TMEM86A | Colon, duodenum, rectum, small intestine | Seminal vesicle, testis | Cerebral cortex | Lung | Adrenal gland, thyroid gland | − | Heart muscle, skeletal muscle, skin |
| TSPAN1 | Appendix, colon, duodenum, rectum, small intestine, stomach, salivary gland | Kidney, endometrium, epididymis, fallopian tube, gall-bladder, prostate, seminal vesicle, testis, urinary bladder, uterine cervix | − | Lung, nasopharynx | Parathyroid gland, pituitary gland, thyroid gland | − | Smooth muscle |
CNS, central nervous system.