Fig. 3.

Gene expression analysis of P2H1 adrenocortical cells. a Gene expression analysis of enzymes involved in the steroidogenesis pathway using mRNA from whole adrenals from P2H1 mice and WT counterparts (n = 10–13). All graphs are the result of 2 independent experiments. b Schematic overview of the RNAseq approach which compared sorted GFP⁺ cells from WT controls and P2H1 mice (n = 3). c Gene signature analysis using Enrichr. d Gene set enrichment analyses (GSEA) showed positive signatures for steroidogenesis-related pathways. e Prominent HIF-related pathways. f The β-catenin nuclear pathway