Table 4.

Risk for CVD events, HF hospitalization, ASCVD events, and all-cause death by sACE2 levels as a continuous variable (natural log)

Outcome	n/N	Model	HR	95% CI	P value
Global CVD	282/497 (56.7%)	1	1.41	1.20–1.65	<0.001
		2	1.34	1.13–1.60	0.001
		3	1.11	0.93–1.34	0.25
HF	260/497 (52.3%)	1	1.40	1.19–1.66	<0.001
		2	1.32	1.10–1.58	0.003
		3	1.07	0.88–1.30	0.48
ASCVD	150/497 (30.2%)	1	1.24	0.99–1.55	0.06
		2	1.09	0.85–1.39	0.49
		3	0.95	0.73–1.24	0.71
All-cause death	190/497 (38.2%)	1	1.26	1.03–1.54	0.02
		2	1.26	1.01–1.57	0.04
		3	1.01	0.80–1.28	0.91

Data are presented as number of events [n] / number at risk [N] (percent) and HR per natural log unit increase for sACE2 with 95% CI.

Model 1 is adjusted by age, sex, and race; model 2 is model 1 plus total cholesterol, HDL-C, current smoking, SBP, antihypertension medication use, diabetes status, lipid-lowering medication use, history of CVD (stroke, total CHD, and HF), and eGFR; model 3 is model 2 plus log hs-cTnI, log hs-cTnT, and log NT-proBNP.