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. 2021 Feb 17;25(5):445–455. doi: 10.1007/s10157-021-02021-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Alox15 expression in 5/6 Nx kidney at the protein level and localization of the mRNA of Alox15 in kidney tissues. a (upper) Representative immunoblots of ALOX15 of kidneys from sham-control and 5/6 nephrectomized (Nx) CKD mice. The band of ALOX15 was confirmed by the absence of ALOX15 band in Alox15^−/− mice samples. (lower) Densitometry analysis of immunoblots. The ALOX15 in 5/6 Nx mouse kidneys was significantly increased compared with sham-control mouse kidneys (P = 0.0078). The number of samples is given at the bottom of the bar graph. Values are mean ± SEM. Unpaired Student’s t test, *P < 0.05. b in situ hybridization of kidneys from 5/6 Nx Alox15^+/+ mice and 5/6 Nx Alox15^−/− mice. In 5/6 Nx mouse kidneys, Alox15 mRNA was strongly expressed in the tubules, especially proximal tubules. The glomerulus had no mRNA expression of Alox15 (the blue border indicates a glomerulus)