Table 2.
Secondary Effectiveness Outcomes Associated With AF With RVR During Sepsis Stratified by Initial AF Medication
| Outcome | β-Blocker (n = 61) | Amiodarone (n = 322) | Calcium Channel Blocker (n = 217) | Digoxin (n = 36) |
|---|---|---|---|---|
| Average change in HR at 1 h | ||||
| Unadjusted | −15.2 (−18.3 to −12.2) | −6.2 (−7.6 to −4.9) | −7.8 (−9.5 to −6.2) | −6.0 (−9.9 to −2.0) |
| Adjusteda | −15.3 (−18.5 to −12.1) | −6.8 (−8.3 to −5.3) | −8.0 (−9.9 to −6.1) | −4.9 (−9.8 to −0.1) |
| Average change in HR at 6 h | ||||
| Unadjusted | −15.9 (−20.0 to −11.8) | −15.0 (−16.8 to −13.3) | −19.1 (−21.3 to −17.0) | −15.9 (−21.2 to −10.6) |
| Adjusteda | −15.2 (−19.2 to −11.2) | −16.3 (−18.1 to −14.4) | −20.5 (−22.8 to −18.1) | −11.3 (−17.2 to −5.3) |
| Average HR during the first 1 h | ||||
| Unadjusted | 118 (114 to 121) | 122 (121 to 124) | 120 (118 to 122) | 126 (121 to 131) |
| Adjusteda | 115 (112 to 118) | 122 (120 to 123) | 122 (120 to 124) | 124 (119 to 129) |
| Average HR during the first 6 h | ||||
| Unadjusted | 112 (108 to 116) | 114 (113 to 116) | 110 (108 to 112) | 117 (112 to 122) |
| Adjusteda | 110 (106 to 114) | 114 (112 to 115) | 110 (108 to 112) | 118 (112 to 123) |
Data are percentage (95% CI) for change values or beats/min (95% CI). AF = atrial fibrillation; HR = heart rate; RVR = rapid ventricular response.
a
Adjusted for HR at the time of initial AF medication administration, age, sex, race or ethnicity, congestive heart failure and asthma or COPD history, mean arterial pressure, sequential organ failure assessment score, vasopressor or inotrope use, magnesium level, potassium level, white blood cell count, troponin I level, hemoglobin oxygen saturation, and presence of mechanical ventilation and hemodialysis.