Table 4.
Multivariate Cox Regression Analyses of Functional, Hemodynamic, and Imaging Parameters: Functional, Hemodynamic, and Imaging Models Combined
| Model | Parameter | Hazard Ratio | 95% CI | P Value | AIC | Concordance |
|---|---|---|---|---|---|---|
| Model 1 + 2: Functional + hemodynamic | Age | 1.01 | 0.98-1.01 | .539 | 268 | 0.69 |
| Sex | 0.43 | 0.21-0.89 | .022 | … | … | |
| 6MWD | 1.00 | 0.99-1.00 | .220 | … | … | |
| RHC-RAP | 1.05 | 0.98-1.13 | .180 | … | … | |
| RHC-Svo2 | 0.95 | 0.90-1.00 | .064 | … | … | |
| Model 1 + 3: Functional + imaging | Age | 1.01 | 0.99-1.04 | .298 | 273 | 0.70 |
| Sex | 0.51 | 0.25-1.05 | .069 | … | … | |
| 6MWD | 1.00 | 0.99-1.00 | .045 | … | … | |
| CMR-RVEF | 0.96 | 0.94-0.99 | .004 | … | … | |
| Model 2 + 3: Hemodynamic + imaging | Age | 1.03 | 1.01-1.05 | .012 | 320 | 0.71 |
| Sex | 0.49 | 0.26-0.95 | .036 | … | … | |
| RHC-RAP | 1.05 | 0.98-1.12 | .180 | … | … | |
| RHC-Svo2 | 0.96 | 0.92-1.01 | .102 | … | … | |
| CMR-RVEF | 0.97 | 0.94-1.00 | .040 | … | … | |
| Model 1 + 2 + 3: Functional + hemodynamic + imaging | Age | 1.02 | 0.99-1.04 | .227 | 266 | 0.69 |
| Sex | 0.47 | 0.23-0.98 | .044 | … | … | |
| 6MWD | 1.00 | 0.99-1.00 | .220 | … | … | |
| RHC-RAP | 1.02 | 0.95-1.10 | .577 | … | … | |
| RHC-Svo2 | 0.98 | 0.92-1.04 | .451 | … | … | |
| CMR-RVEF | 0.97 | 0.94-1.00 | .052 | … | … |
For sex, male patients are used as reference. 6MWD = 6-min walk distance; AIC = Akaike information criterion; CMR = cardiac MRI; RAP = right atrial pressure; RHC = right heart catheterization; RVEF = right ventricular ejection fraction; Svo2 = mixed venous oxygen saturation.