Figure 4.

A-C, Comparison of Clinical Characteristics and Mortality Rates of the Clusters in the COPDGene Cohort. A, The clinical characteristics identified in COPDGene were compared among the three clusters. Global differences for each clinical characteristic among the three clusters were assessed with the use of analysis of variance and found to be statistically significantly different (P < .001). Pairwise differences were assessed with the use of t-tests without adjustment for multiple comparisons. Four asterisks indicate P ≤ .0001. B, The survival rate of the three clusters identified in COPDGene is demonstrated in this Kaplan-Meier curve. Individuals in the emphysema-predominant cluster had the lowest 5-year survival rate; individuals in the preserved cluster had the highest 5-year survival rate. C, The inset table shows the results of multivariable Cox regression analyses that compared the interstitial predominant cluster and emphysema cluster with the preserved cluster. Note that these analyses were adjusted for age, sex, race, smoking status, and FEV₁ at baseline. SGRQ = St. George's Respiratory Questionnaire.