Table 1.
Cohort Characteristics for the COPDGene and Detection of Early Lung Cancer Among Military Personnel Studies
| Study | Preserved | Interstitial Predominant | Emphysema Predominant | Pa |
|---|---|---|---|---|
| COPDGene | ||||
| No. | 2,623 | 1,910 | 740 | … |
| Clinical characteristics | ||||
| Age, mean (SD), y | 60.22 (8.64) | 59.97 (9.10) | 65.57 (7.70) | <.001 |
| Male, No. (%) | 987 (37.6) | 1,364 (71.4) | 431 (58.2) | <.001 |
| Black, No. (%) | 592 (22.6) | 675 (35.3) | 120 (16.2) | <.001 |
| Current smoker, No. (%) | 1,144 (43.6) | 1,087 (56.9) | 153 (20.7) | <.001 |
| Smoking exposure, mean (SD), pack-y | 39.11 (21.09) | 48.35 (28.14) | 55.57 (26.81) | <.001 |
| BMI, mean (SD), kg/m2 | 27.92 (5.56) | 30.97 (6.22) | 25.47 (5.00) | <.001 |
| FEV1, mean (SD), % predicted | 86.58 (20.07) | 73.14 (22.08) | 40.62 (19.91) | <.001 |
| Longitudinal follow up | ||||
| Time between phase 1 and phase 2 visits, mean (SD), y | 5.35 (0.52) | 5.34 (0.56) | 5.31 (0.48) | .409 |
| Total duration of follow up, mean (SD), y | 6.85 (1.83) | 6.18 (2.18) | 5.67 (2.43) | <.001 |
| Died, No. (%) | 232 (9.3) | 323 (18.4) | 299 (42.5) | <.001 |
| Radiologic measures | ||||
| Interstitial features, mean (SD), % lung | 4.55 (2.66) | 7.89 (5.37) | 5.34 (3.27) | <.001 |
| Emphysema, mean (SD), % lung | 3.66 (5.42) | 4.97 (6.63) | 48.65 (15.22) | <.001 |
| Pectoralis muscle area, mean (SD), cm2 | 36.26 (12.38) | 48.64 (16.66) | 30.94 (10.63) | <.001 |
| Airway wall thickness, mean (SD), mm | 0.91 (0.13) | 1.25 (0.19) | 1.08 (0.22) | <.001 |
| Detection of Early Lung Cancer Among Military Personnel | ||||
| No. | 141 | 153 | 66 | |
| Clinical characteristics | ||||
| Age, mean (SD), y | 63.91 (8.11) | 66.14 (7.63) | 68.11 (6.35) | .001 |
| Male, No. (%) | 97 (68.8) | 131 (85.6) | 58 (87.9) | <.001 |
| Black, No. (%) | 13 (10.7) | 32 (22.4) | 12 (19.7) | .041 |
| Current smoker, No. (%) | 68 (51.5) | 64 (45.1) | 24 (38.7) | .227 |
| Smoking exposure, mean (SD), pack-y | 47.01 (25.89) | 49.08 (25.51) | 52.49 (26.56) | .381 |
| BMI, mean (SD), kg/m2 | 27.49 (6.01) | 28.52 (6.13) | 24.40 (5.40) | <.001 |
| FEV1, mean (SD), % predicted | 80.13 (17.27) | 73.49 (18.12) | 54.61 (19.61) | <.001 |
| Radiologic measures | ||||
| Interstitial features, mean (SD), % lung | 7.06 (4.50) | 12.62 (9.31) | 6.81 (8.18) | <.001 |
| Emphysema, mean (SD), % lung | 2.81 (2.77) | 13.08 (8.32) | 52.18 (16.60) | <.001 |
| Pectoralis muscle area, mean (SD), cm2 | 43.04 (13.62) | 47.60 (12.87) | 39.37 (10.08) | <.001 |
| Airway wall thickness, mean (SD), mm | 2.10 (0.35) | 2.22 (0.35) | 2.01 (0.36) | <.001 |
Comparisons of the absolute values of imaging variables between cohorts are limited due to technical differences in image acquisition and reconstruction.
a
Based on analysis of variance for continuous variables and chi-square test for categoric variables.