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. 2021 Apr 7;16:2667–2687. doi: 10.2147/IJN.S306831

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© 2021 Adel et al.

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DSC thermograms of (a) curcumin, (b) lecithin, (c) cholesterol, (d) SA, (e) PLX 188, (f) HPβCYD, (g) SD/P4 improved physical mixture, (h) SD/P6 improved physical mixture, (i) improved SD/P4 formulation and (j) improved SD/P6 formulation. The characteristic endothermic peak of curcumin completely disappeared in the DSC thermograms of the improved SD/P formulations with the shift of the endothermic peak of HPβCD to a lower temperature coupled with a decrease in its intensity, all of which is suggestive of possible interaction and complexation of curcumin in HPβCD (i and j).