Fig. 2. Esterase genes are differentially expressed in newly diagnosed multiple myeloma (n = 41) versus relapsed/refractory multiple myeloma (n = 82) samples in the in-house FIMM dataset.

a DEseq2 differential expression results for 51 esterase genes. b The expression values of genes (n = 6) predicted to be differentially regulated in NDMM versus RRMM groups^a. FIMM Institute for Molecular Medicine Finland, NDMM newly diagnosed multiple myeloma, RPKM reads per kilobase of transcript per million mapped reads, RRMM relapsed/refractory multiple myeloma. ^aBox plots: thick central line represents median; top and bottom lines of box represent third quartile and first quartile; whiskers indicate the variability in the data outside the upper and lower quartile; circles inside the boxplot/distribution represent data point locations; circles outside the boxplot/distribution represent outliers.