Skip to main content
. 2021 Feb 9;124(8):1411–1420. doi: 10.1038/s41416-021-01272-6

Fig. 6. The anti-carcinoma activity of oxaliplatin is dependent on the ERK1/2 activity.

Fig. 6

Colon cancer cells (HROC285, HROC277) were pretreated with 50 µM PD98059 (a, b) or 10 µM U0126 (c, d) for 1 h. Subsequently, these cells were treated by oxaliplatin (OXA) for 48 h. OXA significantly increased the percentage of dead cells, whereas the ERK1/2 inhibitors PD98059 (PD) or U0126 significantly decreased OXA-induced cell death. Moreover, inhibition of the ERK1/2 activity by ERK1/2 siRNA (e) could significantly impair the oxaliplatin-induced cell death (f) too. The P-value was determined by the Mann–Whitney U test. N = 5 for (a), (c) and (d); N = 7 for (b); N = 3 for (e); N = 6 for (f).