Table 2.
BMD changes at the lumbar spine and total hip with associated 95% confidence intervals between baseline and 7 years according to strata and treatment allocation.
Stratum I | Stratum II | Stratum III | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
P (N = 206) | A (N = 205) | P value | P/P (N = 64) | P/R (N = 48) | P value | A/P (N = 53) | A/R (N = 60) | P value | P (N = 43) | A (N = 37) | P value | |
Lumbar spine | −1.37 (−2.16 to −0.57) | −3.94 (−4.71 to −3.17) | 0.0007 | 0.32 (−0.97 to 1.60) | 2.83 (0.92 to 4.74) | 0.175 | −2.37 (−3.97 to −0.77) | 1.34 (−0.11 to .78) | 0.0007 | 3.80 (1.70 to 5.90) | 2.82 (0.91 to 4.74) | 0.99 |
Total hip | −4.31 (−4.91 to −3.71) | −5.06 (−5.72 to −4.40) | 20.7 | −3.85 (−4.87 to −2.83) | −0.31 (−1.74 to 1.12) | 0.0007 | −3.66 (−5.02 to −2.31) | −2.44 (−3.76 to −1.12) | 0.99 | −0.17 (−1.61 to 1.27) | −0.86 (−2.74 to 1.03) | 0.99 |
Women in stratum I had healthy BMD at baseline, those in stratum II were osteopenic, and those in stratum III were osteoporotic. P values are for a comparison between allocated treatment groups. P values are corrected for multiple comparisons.
A Anastrozole, P Placebo, R Risedronate.